The Florida Highway Patrol tweeted that deputies are responding to a fatal crash on First Coast Highway just North of Nassau Bridge.
Troopers say that one person has been pronounced dead on the scene of a two vehicle crash on SR-A1A, just north of the Nassau Sound Bridge.
One patient is being transported to the hospital.
Troopers are asking drivers to seek an alternate route if traveling in that area.
Stay with First Coast News as this story develops.