Interstate-95 South reopened Saturday night after it was shut down by a flipped semi-truck leaking fuel just south of Bowden Road, according to the Jacksonville Sheriff's Office.
Florida Highway Patrol said the crash happened at 4:50 p.m. during heavy rain.
Traffic began to slow quickly, prompting the driver of the semi-truck to brake and lose control of the semi-truck, FHP said.
The semi-truck drifted from the center lane to the left paved shoulder, causing the driver to over-correct by swerving to the right. The semi-truck overturned and blocked the southbound lanes of I-95, FHP said.
As the semi-truck overturned, its fuel tank punctured and leaked about 100 gallons of diesel fuel on the highway.
The entrance ramp to southbound I-95 at Bowden Road was closed for hours as crews, including a Hazmat team, worked to clear the scene.
As of 8:23 p.m., all lanes have reopened.