Something about his hometown team must bring out the best in Derrick Henry.

The Yulee High School grad rushed for 238 yards and four touchdowns, as the Titans (7-6) registered their fourth straight win over their AFC South rival Jaguars (4-9). The 238 yards is a Titans-franchise record.

Less than a week after shutting out the Indianapolis Colts, the Jaguars defense allowed 426 total yards of offense. Titans' quarterback Marcus Mariota was 18 of 24 for 126 yards.

After serving a one-game suspension last week, Jaguars' running back Leonard Fournette was held to 36 yards on 14 carries. Quarterback Cody Kessler was 25 of 43 for 240 yards and one touchdown. Kessler was sacked four times.

The first score for the Jaguars came in the first quarter when Leon Jacobs and a host of Jaguars took advantage of a miscue by the Titans' punt returner. The safety put points on the board and gave the ball right back to Jacksonville. Kessler and the Jaguars would march all the way to the 3-yard line, where they came away with no points.

On the first play of the ensuing drive, Henry went 99 yards for his second touchdown of the game. Henry became just the second running back in NFL history to score a 99-yard touchdown, joining Hall of Famer Tony Dorsett. He added two more touchdowns in the second half.

Dede Westbrook scored his fourth touchdown in the third quarter, a 7-yard grab to make the score 30-9.

Up next for the Jaguars is a home game against the Washington Redskins (6-6) on December 16 at TIAA Bank Field in Jacksonville.