"Of everything there is to celebrate about "Grey's Anatomy," I think I'm most proud of the women."

Creator Shonda Rhimes reflects on her first television series ever, as it reaches its 300-episode milestone.

From its start in 2005, 'Grey's Anatomy' changed the TV landscape and brought us unforgettable characters, relationships we invested in, and moments that made us laugh, cry, and gasp at every turn.

Preview the special ep below and tweet your favorites with hashtag #Greys300 when you watch LIVE at 8:00 on ABC 25.