Chicago, IL (Sports Network) - Welington Castillo stood at home plate and watched.

With two outs, a man on and a run down, the further the fastball he launched traveled down the left-field line and the more dampened, empty seats it passed over, the louder the remaining Wrigley faithful became, eager to punctuate the afternoon tilt with one last dramatic turn.

But the noise quickly turned to silence. Castillo sliced the long fly ball just foul, and soon after Brewers closer Jim Henderson escaped the threat to pick up his 13th save and finish off a 6-5 win in the second of a four-game series.

The game was also the first of a day-night doubleheader, with the nightcap scheduled to start at 8:05.

Jean Segura capped a four-run, come-from-behind seventh inning with a double to help the Brewers overcome the Cubs' five-run fifth and earn their third win in four games.

Yovani Gallardo started for the Brewers and left with two outs in the fifth inning due to a tight left hamstring. He was charged with three runs on six hits and three walks. Rob Wooten (1-0) picked up his first major-league win after tossing a scoreless sixth inning.

Castillo had three hits, knocked in a run and scored another for the Cubs, who lost their second straight.

James Russell (1-3) took the loss after giving up two runs in two-thirds of an inning.