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Denver, CO (Sports Network) - Nolan Arenado hit the go-ahead single in the bottom of the sixth inning as the Colorado Rockies edged the Chicago Cubs, 4-3, in the rubber match of a three-game series at Coors Field.

With Edwin Jackson (6-11) pitching and the game tied at 2-2, Carlos Gonzalez drew a two-out walk and stole second base. Next was Michael Cuddyer, who was also walked. Gonzalez scored on Arenado's base hit to center and Cuddyer scored on a throwing error by center fielder Junior Lake.

Colorado starter Tyler Chatwood (6-3) gave up two runs -- one earned -- on seven hits and four walks over six innings. Rex Brothers allowed one run in the ninth but notched his fifth save.

Anthony Rizzo had a home run while Alfonso Soriano and Darwin Barney drove in one run apiece for the Cubs, who were 0-for-9 with runners in scoring position.

Jackson surrendered four runs -- three earned -- on five hits and a pair of walks in seven frames.

Colorado scored two runs in the first. Charlie Blackmon hit a ground rule double to left with one out. Gonzalez brought him home with a two-out single to left center and scored on a Michael Cuddyer double to right center.

The Cubs didn't have much success offensively, until the sixth. Rizzo led off with a solo shot to left. Nate Schierholtz delivered a one-out single and later scored on a sacrifice fly by Barney, tying the game at 2-2.

They had a chance to take the lead with two out and the bases loaded, but Jackson hit a grounder towards Troy Tulowitzki to end the inning.

In the ninth, Brothers gave up a leadoff double to Starlin Castro. Two batters later, Soriano grounded out but was able to score Castro to cut the deficit to one.

Pinch-hitter Cody Ransom drew a walk with two outs, but Brothers struck out Lake to end the game.

Game Notes

The Cubs were 1-for-24 with runners in scoring position this series and are 173-for-745 (.232) for the season ... Jordan Pacheco pinch-hit in the seventh inning, but grounded out in his only at-bat, ending a 10-game hitting streak ... Brothers has allowed two runs since the All-Star break. He allowed just four runs before the break, including 32 straight scoreless appearances from April 20-June 28.

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